CBX5

Across TCGA patient cohorts, CBX5 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX5-associated genes across cancer lineages are p27_pT198, p62 Lck ligand, and Cyclin-B1. Each is linked with CBX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX5-to-partner and partner-to-CBX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by CBX5-low versus CBX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX5→partner) and Y-score (partner→CBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.106	+2.321	.049	.035	3	2
UCEC	p62 Lck ligand →	+0.536	+3.459	.001	.005	3	1
UCEC	Cyclin-B1 →	+0.759	+2.321	.007	.035	3	1
UCEC	ERK2 →	+0.213	+2.321	.027	.035	1	1
UCEC	Di-Ras3 →	-0.175	-3.459	.019	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p27_pT198 by CBX5 expression — UCEC

Explore this box plot interactively →