CBX5

Across TCGA cell cohorts, CBX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,554 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CBX5-associated GO terms across cancer lineages are Positive regulation of cytokinesis, Centrosome cycle, and Spindle assembly. Each is linked with CBX5 in more than 18 cancer types. Because this analysis shows association rather than direction, both CBX5-to-partner and partner-to-CBX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytokinesis grouped by CBX5-low versus CBX5-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX5→partner) and Y-score (partner→CBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of cytokinesis →	+0.114	+0.866	.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.106	+1.227	<.001	<.001	3	18
BREAST	Spindle assembly →	+0.075	+1.103	<.001	<.001	3	17
BONE	Sister chromatid segregation →	+0.136	+1.221	.003	.001	3	17
BONE	Regulation of DNA-templated DNA replication initiation →	+0.143	+0.943	.002	.003	3	17
BLOOD_Myeloma	Positive regulation of cell division →	+0.128	+1.420	<.001	.007	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,554 associations by consensus.

Positive regulation of cytokinesis by CBX5 expression — PANCREAS

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