CBX5

Across TCGA cell cohorts, CBX5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBX5-associated genes across cancer lineages are MSGN1 and OR2T8. Each is linked with CBX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX5-to-partner and partner-to-CBX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by CBX5-low versus CBX5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX5→partner) and Y-score (partner→CBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR2T8 →	+0.147	+3.693	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MSGN1 by CBX5 expression — LARGE_INTESTINE

Explore this box plot interactively →