CBLIF

Across TCGA patient cohorts, CBLIF mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBLIF-associated genes across cancer lineages are c-Met, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with CBLIF in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLIF-to-partner and partner-to-CBLIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met grouped by CBLIF-low versus CBLIF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLIF→partner) and Y-score (partner→CBLIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Met →	+0.151	+1.891	.026	.030	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.532	-2.321	.006	.034	3	2
UCEC	PDCD4 →	-0.515	-2.115	.012	.019	3	2
UCEC	Src_pY527 →	-0.508	-2.115	.006	.019	3	2
UCEC	Bax →	+0.266	+2.459	.011	.018	3	2
UCEC	ERK2 →	+0.241	+3.321	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

c-Met by CBLIF expression — SKCM

Explore this box plot interactively →