CBLIF

Across TCGA pan-cancer cohorts, CBLIF RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CBLIF data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CBLIF RNA is associated with better overall survival. In most high-consensus cancer types, elevated CBLIF expression acts as an unfavorable survival marker, although some lineages such as COAD and BLCA show a favorable association.

COAD, LUSC, and BLCA are the cancer types where CBLIF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.817	0.409	<.001	85	view →
LUSC	OS	Tertile	II,III,IV	0.285	0.451	.004	81	view →
BLCA	OS	Tertile	All	0.589	0.343	.001	67	view →
SKCM	OS	Tertile	II,III,IV	0.907	0.825	.006	50	view →
HNSC	DFS	Quartile	II,III,IV	0.457	0.309	.015	38	view →
LUAD	DFS	Median	III,IV	0.261	0.517	.006	32	view →
MESO	OS	Quartile	All	0.372	0.592	.006	29	view →
KIRP	DFS	Tertile	II,III,IV	0.783	0.511	.013	25	view →
ESCA	DFS	Quartile	All	0.445	1.000	.018	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
UVM	OS	Tertile	All	0.342	0.727	.009	18	view →
BRCA	OS	Tertile	III,IV	0.706	0.457	.036	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CBLIF–COAD (OS)

Open the COAD breakdown →