CBL

Across TCGA cell cohorts, CBL mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBL-associated genes across cancer lineages are OR1L3, IFNA7, and MYF6. Each is linked with CBL in more than 1 cancer types. Because this analysis shows association rather than direction, both CBL-to-partner and partner-to-CBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by CBL-low versus CBL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBL→partner) and Y-score (partner→CBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	2
BLOOD_Leukemia	IFNA7 →	+0.019	+3.922	<.001	.002	3	2
OESOPHAGUS	MYF6 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	OR4E2 →	+0.133	+4.906	<.001	.006	3	1
OESOPHAGUS	OR4E1 →	+0.016	+4.906	<.001	.006	3	1
BREAST	IL36A →	+0.085	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

OR1L3 by CBL expression — SKIN

Explore this box plot interactively →