CBFB

Across TCGA patient cohorts, CBFB mutation is significantly associated with the RNA expression of many other genes, with 761 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CBFB-associated genes across cancer lineages are FGD3, RNA5SP93, and RNU4-24P. Each is linked with CBFB in more than 1 cancer types. Because this analysis shows association rather than direction, both CBFB-to-partner and partner-to-CBFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGD3 grouped by CBFB-low versus CBFB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBFB→partner) and Y-score (partner→CBFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGD3 →	+1.160	+2.917	.002	.001	3	2
BRCA	RNA5SP93 →	+0.180	+3.046	.002	.007	3	2
BRCA	RNU4-24P →	+0.413	+2.324	.001	.001	3	2
BRCA	RPL31P1 →	+0.056	+3.312	<.001	<.001	3	2
BRCA	LINC01673 →	+0.108	+2.248	.001	.005	3	2
LUSC	RPS8P6 →	+0.295	+4.554	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 761 associations by consensus.

FGD3 by CBFB expression — BRCA

Explore this box plot interactively →