CBFB

Across TCGA pan-cancer cohorts, CBFB RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CBFB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CBFB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CBFB is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where CBFB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CBFB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.976	<.001	12	view →
BLCA	Male	III,IV	+1.708	<.001	11	view →
COAD	All	III,IV	+1.580	<.001	11	view →
KIRC	Male	All	+0.762	<.001	11	view →
STAD	Male	II,III,IV	+1.362	<.001	10	view →
LIHC	Male	II,III,IV	+0.910	<.001	9	view →
KICH	Female	All	−1.060	<.001	8	view →
KIRP	All	III,IV	+0.921	<.001	8	view →
LUAD	Male	II,III,IV	+0.806	<.001	8	view →
THCA	All	All	+0.256	.003	8	view →
READ	All	All	+1.121	<.001	7	view →
BRCA	All	II,III,IV	+0.472	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CBFB–HNSC

Open the HNSC breakdown →