CAVIN1

Across TCGA patient cohorts, CAVIN1 mutation is significantly associated with the RNA expression of many other genes, with 430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAVIN1-associated genes across cancer lineages are HPRT1P3, SENP3-EIF4A1, and CENPH. Each is linked with CAVIN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CAVIN1-to-partner and partner-to-CAVIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPRT1P3 grouped by CAVIN1-low versus CAVIN1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAVIN1→partner) and Y-score (partner→CAVIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HPRT1P3 →	+0.039	+5.757	.001	.001	3	4
UCEC	SENP3-EIF4A1 →	+0.131	+3.269	.001	.008	3	2
UCEC	CENPH →	+0.629	+3.329	.007	.005	3	2
UCEC	RRM1 →	+0.780	+3.700	.005	.001	3	2
UCEC	PLRG1 →	+0.594	+3.338	.001	.005	3	2
UCEC	ZBTB8OS →	+0.360	+3.732	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 430 associations by consensus.

HPRT1P3 by CAVIN1 expression — BRCA

Explore this box plot interactively →