CAVIN1

Across TCGA pan-cancer cohorts, CAVIN1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CAVIN1 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CAVIN1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CAVIN1 expression acts as an unfavorable survival marker, although some lineages such as UVM and ESCA show a favorable association.

MESO, HNSC, and BLCA are the cancer types where CAVIN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.365	0.660	<.001	93	view →
HNSC	DFS	Median	All	0.626	0.762	<.001	71	view →
BLCA	OS	Quartile	II,III,IV	0.308	0.628	.002	68	view →
UVM	DFS	Quartile	All	0.933	0.488	<.001	67	view →
LGG	OS	Median	All	0.714	0.902	<.001	54	view →
ESCA	DFS	Median	III,IV	0.447	0.236	.009	37	view →
COAD	DFS	Tertile	All	0.290	0.587	.001	34	view →
THCA	DFS	Tertile	All	0.954	0.695	.002	34	view →
KIRC	DFS	Quartile	All	0.866	0.529	.001	29	view →
OV	OS	Quartile	II,III,IV	0.235	0.390	.003	22	view →
SARC	OS	Median	All	0.610	0.335	<.001	19	view →
STAD	OS	Tertile	All	0.496	0.634	.021	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CAVIN1–MESO (OS)

Open the MESO breakdown →