CATSPER3

Across TCGA patient cohorts, CATSPER3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CATSPER3-associated genes across cancer lineages are AMPK_pT172, GAPDH, and JNK_pT183_Y185. Each is linked with CATSPER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CATSPER3-to-partner and partner-to-CATSPER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_pT172 grouped by CATSPER3-low versus CATSPER3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CATSPER3→partner) and Y-score (partner→CATSPER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AMPK_pT172 →	+0.441	+2.128	.014	.010	3	2
UCEC	GAPDH →	+0.460	+3.169	.049	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.214	-3.169	.003	.018	3	1
UCEC	JNK2 →	+0.277	+2.115	.001	.019	3	1
UCEC	Ku80 →	+0.305	+2.128	.003	.010	3	1
UCEC	p62 Lck ligand →	+0.411	+3.594	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

AMPK_pT172 by CATSPER3 expression — UCEC

Explore this box plot interactively →