CATSPER3

Across TCGA pan-cancer cohorts, CATSPER3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CATSPER3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CATSPER3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CATSPER3 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where CATSPER3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CATSPER3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.624	<.001	11	view →
COAD	All	II,III,IV	+0.302	<.001	9	view →
LIHC	Female	All	+0.382	<.001	8	view →
BLCA	Male	IV	−0.757	<.001	7	view →
BRCA	All	II,III,IV	+0.331	<.001	6	view →
STAD	All	II,III,IV	+0.390	.001	4	view →
CHOL	All	All	+0.916	<.001	3	view →
THCA	Male	All	−0.278	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CATSPER3–KIRC

Open the KIRC breakdown →