CASTOR2

Across TCGA patient cohorts, CASTOR2 mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASTOR2-associated genes across cancer lineages are FBXL12P1, MIR4694, and RN7SL248P. Each is linked with CASTOR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASTOR2-to-partner and partner-to-CASTOR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXL12P1 grouped by CASTOR2-low versus CASTOR2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR2→partner) and Y-score (partner→CASTOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FBXL12P1 →	+0.056	+5.760	<.001	.003	3	2
BRCA	MIR4694 →	+0.620	+5.841	<.001	.003	3	2
UCEC	RN7SL248P →	+0.070	+3.400	<.001	.003	3	2
BRCA	MIR6072 →	+0.216	+8.057	<.001	.005	3	1
UCEC	FBXO7 →	+0.382	+2.343	.008	.003	3	1
UCEC	L3MBTL2 →	+0.386	+3.500	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

FBXL12P1 by CASTOR2 expression — BRCA

Explore this box plot interactively →