CASP8AP2

Across TCGA patient cohorts, CASP8AP2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,132 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CASP8AP2-associated genes across cancer lineages are SNORD91B, ASPM, and POLE2. Each is linked with CASP8AP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASP8AP2-to-partner and partner-to-CASP8AP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASP8AP2 versus SNORD91B in GBM, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP8AP2→partner) and Y-score (partner→CASP8AP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNORD91B →	+0.827	+0.758	<.001	<.001	3	3
GBM	ASPM →	+1.509	+0.937	<.001	<.001	3	3
LUAD	POLE2 →	+0.996	+0.607	.005	.005	3	3
GBM	FBXO5 →	+1.137	+0.981	<.001	<.001	3	3
GBM	TTK →	+1.359	+0.900	<.001	<.001	3	3
GBM	FANCI →	+1.267	+0.883	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,132 associations by consensus.

CASP8AP2 vs SNORD91B — GBM

Explore this scatter interactively →