CASP8AP2

Across TCGA pan-cancer cohorts, CASP8AP2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CASP8AP2 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CASP8AP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CASP8AP2 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

MESO, ACC, and UCS are the cancer types where CASP8AP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.237	0.541	<.001	105	view →
ACC	DFS	Tertile	All	0.322	0.809	<.001	64	view →
UCS	DFS	Median	IV	0.952	0.367	.001	62	view →
SKCM	OS	Quartile	II,III,IV	0.452	0.243	.003	61	view →
KIRC	DFS	Quartile	All	0.806	0.528	<.001	52	view →
KICH	DFS	Quartile	All	0.551	1.000	.001	47	view →
LIHC	DFS	Quartile	All	0.374	0.613	<.001	36	view →
KIRP	OS	Quartile	All	0.568	0.821	.001	27	view →
GBM	DFS	Tertile	All	0.469	0.193	.001	21	view →
CESC	DFS	Quartile	All	0.454	0.710	.007	18	view →
HNSC	DFS	Median	All	0.764	0.654	.008	15	view →
SCLC	OS	Quartile	All	0.333	0.950	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CASP8AP2–MESO (OS)

Open the MESO breakdown →