CASP3

Across TCGA patient cohorts, CASP3 mutation is significantly associated with the RNA expression of many other genes, with 2,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP3-associated genes across cancer lineages are DEFB103A, MIR6780B, and AQP7P4. Each is linked with CASP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP3-to-partner and partner-to-CASP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB103A grouped by CASP3-low versus CASP3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP3→partner) and Y-score (partner→CASP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DEFB103A →	+0.059	+7.930	<.001	.008	3	2
HNSC	MIR6780B →	+0.459	+5.505	<.001	.004	3	2
CESC	AQP7P4 →	+0.071	+4.539	<.001	.008	3	2
COAD	RNA5SP442 →	+0.561	+4.308	<.001	.009	3	2
UCEC	RNA5SP499 →	+0.092	+3.812	<.001	.008	3	2
SKCM	GPR119 →	+0.040	+3.899	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,832 associations by consensus.

DEFB103A by CASP3 expression — LUAD

Explore this box plot interactively →