CASP3

Across TCGA pan-cancer cohorts, CASP3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CASP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CASP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CASP3 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where CASP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.880	<.001	11	view →
HNSC	Male	All	+0.707	<.001	10	view →
BLCA	Male	All	+0.801	.001	8	view →
LUSC	Female	All	+1.115	<.001	7	view →
KIRP	All	II,III,IV	+0.989	<.001	7	view →
LUAD	Male	II,III,IV	+0.976	<.001	7	view →
STAD	All	II,III,IV	+0.890	<.001	7	view →
LIHC	Male	All	+0.799	<.001	7	view →
UCEC	All	III,IV	+1.259	<.001	6	view →
BRCA	All	II,III,IV	+0.778	<.001	6	view →
ESCA	All	All	+1.186	.006	4	view →
CHOL	Male	All	+1.491	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CASP3–KIRC

Open the KIRC breakdown →