CASC3

Across TCGA patient cohorts, CASC3 protein abundance is significantly associated with the RNA expression of many other genes, with 12,762 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CASC3-associated genes across cancer lineages are TOP2A, CDC7, and PSMD11. Each is linked with CASC3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CASC3-to-partner and partner-to-CASC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASC3 versus TOP2A in GBM, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASC3→partner) and Y-score (partner→CASC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TOP2A →	+1.636	+0.347	<.001	<.001	3	6
LSCC	CDC7 →	+0.661	+0.207	.002	<.001	3	6
LSCC	PSMD11 →	+0.725	+0.201	<.001	<.001	3	5
GBM	KIF14 →	+1.237	+0.296	<.001	<.001	3	5
GBM	BRCA1 →	+0.936	+0.352	<.001	<.001	3	5
UCEC	PLK4 →	+0.687	+0.181	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,762 associations by consensus.

CASC3 vs TOP2A — GBM

Explore this scatter interactively →