CARD18

Across TCGA patient cohorts, CARD18 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,413 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible CARD18-associated GO terms across cancer lineages are Cornified envelope assembly, Establishment of skin barrier, and Epidermal cell differentiation. Each is linked with CARD18 in more than 7 cancer types. Because this analysis shows association rather than direction, both CARD18-to-partner and partner-to-CARD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cornified envelope assembly grouped by CARD18-low versus CARD18-high in HNSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD18→partner) and Y-score (partner→CARD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Cornified envelope assembly →	+0.034	+0.842	<.001	<.001	3	8
ESCA	Establishment of skin barrier →	+0.059	+0.761	<.001	<.001	3	8
ESCA	Epidermal cell differentiation →	+0.054	+1.054	<.001	<.001	3	8
ESCA	Keratinocyte differentiation →	+0.054	+1.033	<.001	<.001	3	8
ESCA	Intermediate filament organization →	+0.104	+1.057	<.001	<.001	3	8
SKCM	Intermediate filament bundle assembly →	+0.251	+0.607	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,413 associations by consensus.

Cornified envelope assembly by CARD18 expression — HNSC

Explore this box plot interactively →