CARD18

Across TCGA cell cohorts, CARD18 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CARD18-associated genes across cancer lineages are SEMG1, CABS1, and GOLGA8F. Each is linked with CARD18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD18-to-partner and partner-to-CARD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG1 grouped by CARD18-low versus CARD18-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD18→partner) and Y-score (partner→CARD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SEMG1 →	+0.026	+4.930	<.001	.001	3	1
SKIN	CABS1 →	+0.034	+4.415	<.001	.007	3	1
SKIN	GOLGA8F →	+0.034	+5.217	<.001	<.001	3	1
SKIN	TERB2 →	+0.017	+4.415	<.001	.007	3	1
SKIN	FADS6 →	+0.293	+4.095	<.001	.009	3	1
SKIN	CYP4Z1 →	+0.265	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SEMG1 by CARD18 expression — SKIN

Explore this box plot interactively →