CARD14

Across TCGA patient cohorts, CARD14 mutation is significantly associated with the RNA expression of many other genes, with 3,510 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD14-associated genes across cancer lineages are GPR50-AS1, ETFDH, and NMNAT1. Each is linked with CARD14 in more than 3 cancer types. Because this analysis shows association rather than direction, both CARD14-to-partner and partner-to-CARD14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR50-AS1 grouped by CARD14-low versus CARD14-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD14→partner) and Y-score (partner→CARD14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GPR50-AS1 →	+0.024	+3.270	.006	.005	3	3
UCEC	ETFDH →	+0.377	+2.103	.002	.003	3	3
UCEC	NMNAT1 →	+0.460	+1.893	<.001	<.001	3	3
UCEC	TIMM22 →	+0.417	+1.946	<.001	<.001	3	3
COAD	RNU6-686P →	+0.426	+4.172	<.001	<.001	3	3
UCEC	SMYD4 →	+0.412	+2.649	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,510 associations by consensus.

GPR50-AS1 by CARD14 expression — BLCA

Explore this box plot interactively →