CARD14

Across TCGA pan-cancer cohorts, CARD14 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CARD14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CARD14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CARD14 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where CARD14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CARD14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.630	<.001	12	view →
COAD	All	III,IV	+1.102	<.001	11	view →
LUAD	Male	All	+1.439	<.001	9	view →
LUSC	Male	All	+1.546	<.001	8	view →
READ	All	All	+1.056	<.001	7	view →
BLCA	Male	All	+1.307	.004	6	view →
BRCA	All	II,III,IV	+0.616	<.001	6	view →
KICH	All	All	−0.217	<.001	5	view →
CHOL	All	All	+1.458	<.001	3	view →
KIRP	All	All	+0.380	.002	3	view →
UCEC	All	All	+0.558	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CARD14–KIRC

Open the KIRC breakdown →