CARD14

Across TCGA pan-cancer cohorts, CARD14 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CARD14 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CARD14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CARD14 expression acts as an unfavorable survival marker, although some lineages such as SARC and SCLC show a favorable association.

ACC, UVM, and KIRC are the cancer types where CARD14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.211	0.695	<.001	108	view →
UVM	DFS	Quartile	All	0.272	0.838	<.001	104	view →
KIRC	DFS	Median	All	0.537	0.712	<.001	86	view →
KIRP	DFS	Tertile	III,IV	0.512	0.860	.004	58	view →
LIHC	DFS	Median	All	0.473	0.609	.001	41	view →
SARC	DFS	Tertile	All	0.576	0.387	.001	37	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	27	view →
UCEC	DFS	Tertile	All	0.444	0.799	.002	26	view →
MESO	OS	Median	All	0.491	0.283	.002	24	view →
LUAD	DFS	Quartile	All	0.699	0.843	.002	14	view →
PRAD	DFS	Tertile	All	0.826	0.922	.005	14	view →
LGG	OS	Median	All	0.958	0.855	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CARD14–ACC (DFS)

Open the ACC breakdown →