CARD14

Across TCGA patient cohorts, CARD14 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD14-associated genes across cancer lineages are TFRC, TSC1, and PI3K-p85. Each is linked with CARD14 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARD14-to-partner and partner-to-CARD14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by CARD14-low versus CARD14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD14→partner) and Y-score (partner→CARD14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.444	+1.440	.015	.024	3	3
COAD	TSC1 →	-0.353	-3.000	.006	.034	3	3
BLCA	PI3K-p85 →	-0.237	-3.321	.007	.010	3	2
UCEC	MEK1 →	+0.294	+1.847	.020	.007	3	2
UCEC	mTOR_pS2448 →	-0.149	-2.209	.003	.009	3	2
UCEC	Rad50 →	-0.253	-1.440	.002	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

TFRC by CARD14 expression — UCEC

Explore this box plot interactively →