CARD14

Across TCGA cell cohorts, CARD14 mutation is significantly associated with the RNA expression of many other genes, with 705 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARD14-associated genes across cancer lineages are GAGE10, UPP2, and KLRC1. Each is linked with CARD14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD14-to-partner and partner-to-CARD14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE10 grouped by CARD14-low versus CARD14-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD14→partner) and Y-score (partner→CARD14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GAGE10 →	+0.073	+4.736	<.001	.009	3	2
BLOOD_Lymphoma	UPP2 →	+0.041	+4.192	<.001	.003	3	2
SKIN	KLRC1 →	+0.080	+3.789	<.001	.004	3	2
SKIN	PSKH2 →	+0.020	+3.632	<.001	.003	3	2
BLOOD_Leukemia	NPFFR1 →	+0.012	+2.774	<.001	.006	3	2
BLOOD_Leukemia	SOX1 →	+0.337	+2.979	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 705 associations by consensus.

GAGE10 by CARD14 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →