CARD10

Across TCGA cell cohorts, CARD10 mutation is significantly associated with the mutation status of many other genes, with 5,347 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARD10-associated genes across cancer lineages are TRPA1, PLXNB1, and TSC2. Each is linked with CARD10 in more than 5 cancer types. Because this analysis shows association rather than direction, both CARD10-to-partner and partner-to-CARD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPA1 grouped by CARD10-low versus CARD10-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD10→partner) and Y-score (partner→CARD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TRPA1 →	+3.619	+3.619	<.001	<.001	1	6
CNS	PLXNB1 →	+4.459	+5.277	.005	.005	1	5
OVARY	TSC2 →	+2.560	+2.688	.008	.008	1	5
OVARY	WDR81 →	+3.619	+3.619	<.001	<.001	1	5
LARGE_INTESTINE	KIAA1549 →	+1.416	+2.473	.002	.002	1	5
LARGE_INTESTINE	UTRN →	+1.834	+3.370	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,347 associations by consensus.

TRPA1 by CARD10 expression — OVARY

Explore this box plot interactively →