CARD10

Across TCGA pan-cancer cohorts, CARD10 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CARD10’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CARD10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CARD10 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

LIHC, HNSC, and KICH are the cancer types where CARD10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CARD10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	III,IV	+1.412	<.001	9	view →
HNSC	Male	All	+1.150	<.001	9	view →
KICH	Female	All	−2.275	<.001	8	view →
KIRC	Female	All	+0.826	<.001	7	view →
STAD	Male	II,III,IV	+1.764	<.001	6	view →
CHOL	Male	All	+2.243	<.001	5	view →
LUAD	All	II,III,IV	+0.664	<.001	5	view →
ESCA	All	All	+1.218	.028	4	view →
BRCA	Female	II,III,IV	−0.722	<.001	4	view →
THCA	All	All	+0.331	<.001	3	view →
READ	All	III,IV	+0.625	.026	2	view →
COAD	Male	All	+0.350	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CARD10–LIHC

Open the LIHC breakdown →