CAPN5

Across TCGA patient cohorts, CAPN5 mutation is significantly associated with the RNA expression of many other genes, with 3,406 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN5-associated genes across cancer lineages are ICMT, EIF5A, and THAP3. Each is linked with CAPN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN5-to-partner and partner-to-CAPN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ICMT grouped by CAPN5-low versus CAPN5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN5→partner) and Y-score (partner→CAPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ICMT →	+0.442	+3.584	.001	.002	3	3
COAD	EIF5A →	+0.549	+3.611	.001	.001	3	3
COAD	THAP3 →	+0.323	+3.625	.003	.001	3	3
READ	HMGB1P13 →	+0.100	+3.470	.002	.005	3	2
READ	RNU6-130P →	+0.759	+3.708	.001	.006	3	2
READ	SNRPEP7 →	+0.190	+3.730	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,406 associations by consensus.

ICMT by CAPN5 expression — COAD

Explore this box plot interactively →