CAPN5

Across TCGA pan-cancer cohorts, CAPN5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CAPN5 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher CAPN5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CAPN5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRC show a favorable association.

KICH, MESO, and UCEC are the cancer types where CAPN5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	II,III,IV	0.774	1.000	<.001	98	view →
MESO	OS	Median	II,III,IV	0.446	0.660	<.001	93	view →
UCEC	DFS	Median	All	0.438	0.805	<.001	80	view →
LGG	OS	Median	All	0.707	0.920	<.001	54	view →
BLCA	OS	Quartile	All	0.667	0.412	<.001	54	view →
LUSC	DFS	Tertile	All	0.694	0.791	.005	47	view →
KIRC	DFS	Tertile	All	0.745	0.413	<.001	42	view →
UVM	OS	Median	All	0.436	0.789	.002	42	view →
ESCA	OS	Tertile	All	0.436	1.000	.006	27	view →
BRCA	DFS	Tertile	III,IV	0.668	0.400	.001	24	view →
KIRP	DFS	Tertile	All	0.963	0.852	.004	22	view →
UCS	DFS	Tertile	IV	0.321	0.871	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CAPN5–KICH (OS)

Open the KICH breakdown →