CAPN5

Across TCGA pan-cancer cohorts, CAPN5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CAPN5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CAPN5 RNA is repressed in tumor relative to normal tissue. In most cancer types CAPN5 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and LUAD are the cancer types where CAPN5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAPN5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.885	<.001	11	view →
HNSC	All	IV	−1.755	<.001	11	view →
LUAD	Male	II,III,IV	+1.617	<.001	9	view →
KIRC	Male	III,IV	−1.311	<.001	9	view →
COAD	Female	All	−1.258	<.001	9	view →
READ	All	II,III,IV	−1.522	.001	6	view →
UCEC	All	All	−1.074	<.001	6	view →
BRCA	All	All	−0.686	<.001	6	view →
PAAD	All	All	+2.457	.013	2	view →
LIHC	Male	All	+0.614	.005	2	view →
THCA	All	All	−0.333	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CAPN5–KICH

Open the KICH breakdown →