CAPN5

Across TCGA patient cohorts, CAPN5 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN5-associated genes across cancer lineages are Annexin-1, C-Raf, and eEF2. Each is linked with CAPN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN5-to-partner and partner-to-CAPN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by CAPN5-low versus CAPN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN5→partner) and Y-score (partner→CAPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.684	+2.267	<.001	<.001	3	3
UCEC	C-Raf →	+0.185	+2.070	<.001	.001	3	3
UCEC	eEF2 →	+0.306	+2.000	.006	.029	3	2
UCEC	FoxM1 →	+0.162	+1.353	.047	.015	3	2
COAD	Lck →	+0.376	+2.195	.008	.034	3	2
UCEC	MEK1 →	+0.415	+2.115	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Annexin-1 by CAPN5 expression — UCEC

Explore this box plot interactively →