CAPN5

Across TCGA cell cohorts, CAPN5 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CAPN5-associated genes across cancer lineages are FAM205A, PRB2, and KCND3. Each is linked with CAPN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN5-to-partner and partner-to-CAPN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by CAPN5-low versus CAPN5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN5→partner) and Y-score (partner→CAPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.028	+4.351	<.001	<.001	3	1
BLOOD_Leukemia	PRB2 →	+0.111	+2.584	<.001	.006	3	1
BLOOD_Leukemia	KCND3 →	+0.031	+2.933	.003	.008	3	1
BLOOD_Leukemia	PRIMA1 →	+0.025	+2.604	<.001	.006	3	1
BLOOD_Leukemia	MRGPRG →	+0.117	+2.556	.002	.007	3	1
BLOOD_Leukemia	CCT8L2 →	+0.009	+2.967	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FAM205A by CAPN5 expression — LARGE_INTESTINE

Explore this box plot interactively →