CAMKK2

Across TCGA patient cohorts, CAMKK2 mutation is significantly associated with the RNA expression of many other genes, with 2,708 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAMKK2-associated genes across cancer lineages are RNU6-921P, RPS27AP14, and RNU6-1096P. Each is linked with CAMKK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAMKK2-to-partner and partner-to-CAMKK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-921P grouped by CAMKK2-low versus CAMKK2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMKK2→partner) and Y-score (partner→CAMKK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-921P →	+0.446	+5.421	<.001	.005	3	2
READ	RPS27AP14 →	+0.128	+6.257	<.001	.001	3	2
READ	RNU6-1096P →	+0.550	+5.925	<.001	.002	3	2
SKCM	TM9SF1 →	+0.592	+3.328	<.001	.005	3	2
SKCM	PFDN1 →	+0.559	+3.378	<.001	.004	3	2
SKCM	TTC1 →	+0.542	+3.247	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,708 associations by consensus.

RNU6-921P by CAMKK2 expression — READ

Explore this box plot interactively →