CAMKK2

Across TCGA pan-cancer cohorts, CAMKK2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CAMKK2 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CAMKK2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CAMKK2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

MESO, ACC, and LIHC are the cancer types where CAMKK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.265	0.459	<.001	117	view →
ACC	DFS	Median	All	0.254	0.620	<.001	68	view →
LIHC	DFS	Quartile	All	0.399	0.625	<.001	50	view →
BRCA	OS	Quartile	III,IV	0.805	0.543	<.001	44	view →
HNSC	DFS	Quartile	IV	0.730	0.520	.006	43	view →
UVM	DFS	Quartile	All	0.213	0.749	<.001	28	view →
LUSC	DFS	Median	III,IV	0.523	0.916	.009	27	view →
KIRC	DFS	Quartile	III,IV	0.556	0.857	.004	26	view →
GBM	OS	Median	All	0.555	0.272	.001	21	view →
CESC	DFS	Tertile	All	0.643	0.818	.004	16	view →
KICH	OS	Median	III,IV	0.357	0.907	.006	16	view →
CHOL	DFS	Median	All	0.866	0.122	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CAMKK2–MESO (DFS)

Open the MESO breakdown →