CAMKK2

Across TCGA pan-cancer cohorts, CAMKK2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CAMKK2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CAMKK2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CAMKK2 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where CAMKK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAMKK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.925	<.001	11	view →
KIRC	Male	IV	+0.841	<.001	11	view →
THCA	All	III,IV	−0.488	<.001	9	view →
KIRP	Female	All	+0.857	<.001	8	view →
LIHC	All	II,III,IV	+0.777	<.001	8	view →
UCEC	All	All	−0.629	<.001	6	view →
STAD	All	II,III,IV	+0.571	.004	4	view →
LUAD	Female	All	−0.385	.001	4	view →
BRCA	Female	II,III,IV	−0.202	.001	4	view →
CHOL	All	All	+1.666	<.001	3	view →
BLCA	All	IV	−0.872	.007	3	view →
PRAD	All	All	+1.599	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CAMKK2–HNSC

Open the HNSC breakdown →