CAMKK2

Across TCGA patient cohorts, CAMKK2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAMKK2-associated genes across cancer lineages are VHL, Cyclin-B1, and EGFR_pY1068. Each is linked with CAMKK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAMKK2-to-partner and partner-to-CAMKK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CAMKK2-low versus CAMKK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMKK2→partner) and Y-score (partner→CAMKK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.906	-1.925	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.663	+2.321	.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.237	-2.321	.008	.001	3	1
UCEC	eIF4E →	+0.192	+2.222	.011	.010	2	2
UCEC	ERK2 →	+0.203	+2.584	.003	.010	3	1
UCEC	ACC_pS79 →	+0.382	+1.925	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

VHL by CAMKK2 expression — UCEC

Explore this box plot interactively →