CAMKK2

Across TCGA cell cohorts, CAMKK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,138 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CAMKK2-associated GO terms across cancer lineages are CAMKK-AMPK signaling cascade, Regulation of translation at postsynapse, modulating synaptic transmission, and Third ventricle development. Each is linked with CAMKK2 in more than 19 cancer types. Because this analysis shows association rather than direction, both CAMKK2-to-partner and partner-to-CAMKK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAMKK-AMPK signaling cascade grouped by CAMKK2-low versus CAMKK2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMKK2→partner) and Y-score (partner→CAMKK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CAMKK-AMPK signaling cascade →	+0.166	+0.919	<.001	<.001	3	20
BLOOD_Lymphoma	Regulation of translation at postsynapse, modulating synaptic transmission →	+0.106	+0.924	.003	<.001	3	11
BREAST	Third ventricle development →	+0.170	+0.818	<.001	<.001	3	11
OVARY	Negative regulation of DNA-templated transcription initiation →	+0.116	+0.840	<.001	<.001	3	11
OVARY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.135	+0.770	<.001	.002	3	11
OVARY	Negative regulation of transcription initiation by RNA polymerase II →	+0.116	+0.840	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

CAMKK-AMPK signaling cascade by CAMKK2 expression — STOMACH

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