CALY

Across TCGA patient cohorts, CALY mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALY-associated genes across cancer lineages are Heregulin, p62 Lck ligand, and VEGFR2. Each is linked with CALY in more than 1 cancer types. Because this analysis shows association rather than direction, both CALY-to-partner and partner-to-CALY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by CALY-low versus CALY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALY→partner) and Y-score (partner→CALY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.143	-3.169	.034	.020	3	1
UCEC	p62 Lck ligand →	+0.482	+3.009	.006	.019	3	1
UCEC	VEGFR2 →	+0.329	+3.183	.043	.010	3	1
UCEC	eIF4E →	+0.267	+3.169	.021	.020	2	1
UCEC	Rad50 →	-0.359	-3.169	.007	.020	2	1
UCEC	Caspase-8 →	-0.364	-3.169	.008	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Heregulin by CALY expression — UCEC

Explore this box plot interactively →