CALY

Across TCGA pan-cancer cohorts, CALY RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CALY data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CALY RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CALY expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

KIRC, UVM, and BRCA are the cancer types where CALY RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.535	0.710	<.001	120	view →
UVM	DFS	Tertile	II,III,IV	0.410	0.780	<.001	99	view →
BRCA	OS	Tertile	IV	0.812	0.281	.002	45	view →
PAAD	OS	Median	All	0.514	0.291	<.001	42	view →
SKCM	OS	Median	IV	0.886	0.361	.002	37	view →
HNSC	DFS	Quartile	III,IV	0.499	0.255	.002	33	view →
PRAD	DFS	Tertile	All	0.684	0.925	<.001	28	view →
KICH	OS	Quartile	III,IV	0.612	0.967	.004	26	view →
CESC	OS	Tertile	IV	0.809	0.239	.002	24	view →
READ	OS	Quartile	All	0.769	1.000	.002	24	view →
LGG	DFS	Quartile	All	0.817	0.610	.006	19	view →
STAD	OS	Median	III,IV	0.260	0.470	.015	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CALY–KIRC (OS)

Open the KIRC breakdown →