CALY

Across TCGA pan-cancer cohorts, CALY RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CALY’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CALY RNA is repressed in tumor relative to normal tissue. In most cancer types CALY is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and STAD are the cancer types where CALY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CALY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−0.031	.001	8	view →
COAD	Male	II,III,IV	−0.774	<.001	7	view →
STAD	All	All	−1.029	<.001	6	view →
LIHC	All	All	+0.357	.001	5	view →
KICH	All	All	−0.107	<.001	5	view →
BRCA	All	II,III,IV	+0.123	.011	4	view →
LUSC	Female	II,III,IV	−0.177	<.001	3	view →
READ	All	All	−1.050	<.001	2	view →
LUAD	All	All	+0.220	.014	2	view →
ESCA	All	All	−0.546	.038	1	view →
KIRP	Female	All	+0.050	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CALY–HNSC

Open the HNSC breakdown →