CALR3

Across TCGA patient cohorts, CALR3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALR3-associated genes across cancer lineages are eIF4E, MEK1, and p27_pT157. Each is linked with CALR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALR3-to-partner and partner-to-CALR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CALR3-low versus CALR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALR3→partner) and Y-score (partner→CALR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.177	+1.440	.015	.024	3	2
UCEC	MEK1 →	+0.348	+1.736	.006	.007	3	2
UCEC	p27_pT157 →	-0.048	-1.867	.016	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.760	+3.807	<.001	<.001	3	2
UCEC	c-Kit →	-0.205	-1.440	.011	.024	3	2
SKCM	Smad4 →	+0.173	+2.841	.003	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by CALR3 expression — UCEC

Explore this box plot interactively →