CALR3

Across TCGA pan-cancer cohorts, CALR3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CALR3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CALR3 RNA is repressed in tumor relative to normal tissue. In most cancer types CALR3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where CALR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CALR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.125	<.001	9	view →
KICH	All	II,III,IV	−0.154	<.001	8	view →
BRCA	All	All	+0.119	.012	6	view →
LUSC	All	All	+0.141	<.001	4	view →
LIHC	Male	All	+0.126	.001	4	view →
LUAD	All	All	+0.120	.009	4	view →
HNSC	Male	IV	+0.100	.026	3	view →
KIRP	Male	All	−0.066	.008	3	view →
PRAD	All	All	+0.050	.008	2	view →
COAD	All	III,IV	−0.033	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CALR3–THCA

Open the THCA breakdown →