CALR3

Across TCGA pan-cancer cohorts, CALR3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CALR3 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher CALR3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CALR3 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUAD show a favorable association.

KICH, UVM, and UCS are the cancer types where CALR3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.745	1.000	<.001	101	view →
UVM	DFS	Tertile	All	0.285	0.946	<.001	58	view →
UCS	OS	Median	II,III,IV	0.565	0.238	.009	46	view →
LUAD	DFS	Median	II,III,IV	0.674	0.439	.001	38	view →
KIRC	OS	Quartile	All	0.493	0.678	.005	37	view →
LGG	DFS	Median	All	0.677	0.799	<.001	36	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	34	view →
THCA	OS	Median	All	0.957	0.989	.005	26	view →
SCLC	DFS	Tertile	II,III,IV	0.617	0.209	.002	25	view →
BLCA	OS	Tertile	All	0.622	0.324	.018	16	view →
LUSC	DFS	Tertile	All	0.806	0.707	.008	16	view →
READ	DFS	Tertile	IV	0.305	0.690	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CALR3–KICH (DFS)

Open the KICH breakdown →