CALR3

Across TCGA cell cohorts, CALR3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CALR3-associated genes across cancer lineages are LALBA, VN1R3, and PABPC1L2A. Each is linked with CALR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALR3-to-partner and partner-to-CALR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LALBA grouped by CALR3-low versus CALR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALR3→partner) and Y-score (partner→CALR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LALBA →	+0.031	+4.922	<.001	.009	3	1
BLOOD_Leukemia	VN1R3 →	+0.021	+5.539	.006	.003	3	1
BLOOD_Leukemia	PABPC1L2A →	+0.253	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	TSPY4 →	+1.336	+4.922	<.001	.009	3	1
BLOOD_Leukemia	TSPY1 →	+0.705	+5.539	.004	.003	3	1
SKIN	INSL5 →	+0.048	+4.467	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

LALBA by CALR3 expression — BLOOD_Leukemia

Explore this box plot interactively →