CALHM3

Across TCGA patient cohorts, CALHM3 mutation is significantly associated with the RNA expression of many other genes, with 695 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALHM3-associated genes across cancer lineages are RN7SL810P, RN7SL248P, and OR2D2. Each is linked with CALHM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM3-to-partner and partner-to-CALHM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL810P grouped by CALHM3-low versus CALHM3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM3→partner) and Y-score (partner→CALHM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL810P →	+0.176	+4.874	.003	.002	3	2
UCEC	RN7SL248P →	+0.084	+3.606	<.001	.002	3	2
CESC	OR2D2 →	+0.086	+4.276	<.001	.008	3	1
CESC	TERF1P1 →	+0.051	+4.760	<.001	.003	3	1
CESC	C14orf177 →	+0.060	+4.539	<.001	.008	3	1
CESC	RNU6-838P →	+0.293	+5.144	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 695 associations by consensus.

RN7SL810P by CALHM3 expression — CESC

Explore this box plot interactively →