CALHM3

Across TCGA pan-cancer cohorts, CALHM3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CALHM3’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where CALHM3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CALHM3 is over-expressed in tumor, although a few such as PRAD and COAD show the opposite, repressed pattern.

BRCA, LUAD, and STAD are the cancer types where CALHM3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CALHM3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	+0.104	<.001	6	view →
LUAD	Male	II,III,IV	+0.446	<.001	5	view →
STAD	All	All	+0.673	.024	4	view →
COAD	Female	II,III,IV	+0.273	.007	4	view →
HNSC	All	All	+0.164	.012	3	view →
PAAD	All	All	+2.895	.044	2	view →
READ	All	All	+0.226	.025	2	view →
PRAD	All	All	−0.094	<.001	2	view →
CHOL	All	All	+0.214	.037	1	view →
LUSC	Male	All	+0.146	.010	1	view →
COAD	Male	III,IV	−0.077	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

CALHM3–BRCA

Open the BRCA breakdown →