Across TCGA cell cohorts, CALHM1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CALHM1-associated genes across cancer lineages are OR52N5, PRSS54, and C14orf180. Each is linked with CALHM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM1-to-partner and partner-to-CALHM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM1→partner) and Y-score (partner→CALHM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR52N5 →	+0.013	+5.754	<.001	.002	3	1
LARGE_INTESTINE	PRSS54 →	+0.038	+3.345	<.001	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.102	+3.155	.002	.008	3	1
LARGE_INTESTINE	TRARG1 →	+0.022	+3.345	<.001	.007	3	1
LARGE_INTESTINE	IBSP →	+0.179	+3.994	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

CALHM1 survival (RNA) · tumor vs normal (RNA) · all CALHM1 data types