CALCA

Across TCGA patient cohorts, CALCA mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALCA-associated genes across cancer lineages are RNA5SP393, GAGE12H, and MREGP1. Each is linked with CALCA in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCA-to-partner and partner-to-CALCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP393 grouped by CALCA-low versus CALCA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCA→partner) and Y-score (partner→CALCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP393 →	+0.280	+2.609	<.001	.006	3	2
LUAD	GAGE12H →	+0.229	+4.333	<.001	.005	3	2
BRCA	MREGP1 →	+0.827	+5.575	<.001	.004	3	2
LUSC	RN7SKP214 →	+0.188	+2.573	.008	.009	3	2
LUSC	TRIM51BP →	+0.307	+3.063	<.001	.003	3	2
LUSC	PHF5FP →	+0.233	+3.042	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

RNA5SP393 by CALCA expression — LUAD

Explore this box plot interactively →