CALB2

Across TCGA patient cohorts, CALB2 mutation is significantly associated with the RNA expression of many other genes, with 324 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CALB2-associated genes across cancer lineages are MS4A5, IQCF5, and RN7SL735P. Each is linked with CALB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALB2-to-partner and partner-to-CALB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A5 grouped by CALB2-low versus CALB2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALB2→partner) and Y-score (partner→CALB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	MS4A5 →	+0.049	+5.000	.009	.009	3	2
COAD	IQCF5 →	+0.082	+4.721	<.001	.004	3	2
LUSC	RN7SL735P →	+0.163	+3.780	.001	.002	3	2
LUAD	MAML2 →	-1.010	-3.447	<.001	.005	3	2
LUAD	MIR4731 →	+0.447	+2.211	.001	.009	3	2
LUAD	OR51C4P →	+0.016	+4.277	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 324 associations by consensus.

MS4A5 by CALB2 expression — PRAD

Explore this box plot interactively →