CALB2

Across TCGA pan-cancer cohorts, CALB2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CALB2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CALB2 RNA is repressed in tumor relative to normal tissue. In most cancer types CALB2 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, KIRP, and KIRC are the cancer types where CALB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CALB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.040	<.001	11	view →
KIRP	All	All	+0.804	<.001	7	view →
KIRC	Male	III,IV	+0.582	<.001	7	view →
BRCA	All	III,IV	−2.723	<.001	6	view →
THCA	All	All	+0.499	.001	5	view →
CHOL	All	All	+2.994	.001	4	view →
LIHC	Female	All	+0.226	.008	3	view →
READ	Female	All	−3.158	<.001	2	view →
LUAD	Female	III,IV	−1.359	.012	2	view →
UCEC	All	All	−0.885	.040	2	view →
PRAD	All	All	−0.414	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CALB2–COAD

Open the COAD breakdown →